Recruiting

Testing a clot-busting medication for stroke between 4.5 and 6 hours

Plain-English translation of NCT06010628 on ClinicalTrials.gov ↗ · Source last updated September 2026 · Translation generated August 2026 · How we translate trials

Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

Most stroke medications only work within the first 4.5 hours after a stroke starts. This trial is testing whether , a clot-busting medication, can also help people who arrive at the hospital a bit later—between 4.5 and 6 hours after their stroke began. The goal is to see if this medication is safe and effective during this extended window.

Currently, stroke-busting treatments have a narrow time window to work. This trial exists to find out whether this medication can safely extend that window, giving more stroke patients a chance to receive this life-saving treatment.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with an acute ischemic stroke confirmed by CT imaging
you arrive at the hospital between 4.5 and 6 hours after your stroke began
your stroke is causing moderate symptoms (measured as a score of 4 or higher on a standard stroke severity scale)
this is your first stroke, or you had a previous stroke but recovered well with minimal lasting effects

You likely don't qualify if…

you have had a significant stroke or brain injury in the past 3 months
you have a history of bleeding in the brain or are at very high risk for bleeding
you have had major surgery or a heart attack within the past 3 months
you are currently taking blood thinners like warfarin at high doses, or have received heparin within the last 24 hours
you have uncontrolled high blood pressure, very low blood sugar, severe bleeding, or other serious medical conditions

What participation looks like

If you qualify and agree to participate, you will be randomly assigned to receive either the medication or standard stroke care. Participants in the medication group will receive through an IV, along with monitoring to track how well the treatment works and any side effects. You will likely have follow-up visits and tests to measure your recovery over time. The exact schedule will depend on what the hospital team sets up for the trial.

AI-generated summary from trial data · Aug 27, 2026 · Not medical advice

Trial locations(2 sites)

China

Hui-Sheng Chen, Shenyang, None Selected

Department of Neurology, General Hospital of Northern Theater Command, Shenyang