Plain-English translation of NCT06012734 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a combination of two medications: and , given together to treat colorectal cancer that has spread to other parts of the body. The study is designed to find the right dose of when combined with , and to see how well this combination works and what side effects it causes. Researchers believe combining these two medications may work better than either one alone.
Colorectal cancer that has spread to other parts of the body and no longer responds to standard treatments is very difficult to treat. This medication combination is designed to work in new ways to help the body's immune system fight the cancer.
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If you join this trial, you will receive two intravenous infusions every 21 days: on days 1 and 3, and on day 1. You will have regular blood tests and CT scans to monitor how the cancer responds and watch for side effects. You will also have tumor biopsies at the start and during treatment to help researchers understand how the medications are working. The trial is divided into two phases: first, doctors find the right dose of to use with the standard dose of , and then they expand the study to test that dose in more patients.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
Netherlands