Plain-English translation of NCT06013592 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how your body controls appetite and eating through two gut hormones called LEAP2 and acyl ghrelin. One hormone (acyl ghrelin) makes you feel hungry, while the other (LEAP2) helps reduce hunger — and they work in opposite directions. This study will measure how these hormones change in your blood after you drink liquid meals of different sizes, and whether those changes affect how hungry you feel and how much you eat later.
People with obesity have different levels of these hunger-controlling hormones compared to people without obesity. By understanding how these hormones respond to different meal sizes, researchers hope to learn new ways to help people manage their weight and appetite.
You will visit the research center 4 times. At each visit, after fasting overnight, you will drink one liquid meal containing a different number of calories (ranging from zero to up to 1,800 calories, depending on your weight group). The researchers will take blood samples before and after you drink the meal to measure your hunger hormones, ask you about how hungry you feel, and later offer you a lunch buffet to see how much you naturally eat. Each visit takes several hours.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United Kingdom