Plain-English translation of NCT06015776 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are studying how the heart's energy-producing structures (called mitochondria) and blood vessel signaling work differently in postmenopausal women compared to men. By collecting blood and tissue samples from patients undergoing heart surgery, the team hopes to understand why women after menopause develop heart problems even when their coronary arteries look normal on imaging. This research could eventually lead to better treatments for a common type of heart failure in older women.
Heart disease is the leading cause of death in American women, and many postmenopausal women develop heart failure without clear blockages in their arteries. Scientists believe that the loss of estrogen after menopause may disrupt how the heart produces energy and how blood vessels function, but they don't fully understand these mechanisms yet. This study aims to fill that gap by examining the cellular and molecular changes that occur.
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If you qualify and enroll, researchers will collect blood and heart tissue samples during your scheduled heart surgery—no extra procedures beyond what your surgery already requires. The study team will analyze these samples in the laboratory to measure how well your heart's energy production and blood vessel signaling are working. There are no additional visits or follow-up appointments required; participation ends after your surgery.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Sponsor
Beth Israel Deaconess Medical Center
Enrollment target
~500 participants
Started
July 2019
Primary completion
June 2030
Age range
30 Years – 88 Years
Last updated on clinicaltrials.gov in March 2026.
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Central contact
Robina Matyal, MD
Beth Israel Deaconess Medical Center, Professor of Anesthesia
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.