Can a steroid pill help prevent migraines from returning after nerve treatment?

This trial is testing whether adding a single dose of dexamethasone—an oral steroid medication—after a nerve block procedure can prevent migraines from returning within 72 hours. Nerve blocks are a type of pain-relief treatment where medication is injected near nerves to reduce headache pain. Researchers want to see if this medication can help keep the pain from coming back after the nerve block works.

Many migraine patients who get treated in the emergency department find their headache returns within a few days, even after initial treatment helps. This study is the first to test whether adding this medication to a nerve block procedure—instead of other common migraine treatments—can better prevent that painful return.