Plain-English translation of NCT06027294 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Stroke research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research looks at how blood flow to muscles changes after a stroke, especially when those muscles are working hard. Stroke survivors often have trouble with muscle fatigue and weakness on their affected side. The study will test whether a simple, non-invasive procedure called ischemic conditioning—using a blood pressure cuff to briefly squeeze the affected leg—can help improve muscle strength and reduce fatigue.
After a stroke, muscles on the affected side don't work as well as they should, partly because blood flow to those muscles isn't regulated properly during exercise. Researchers want to understand this problem better and find out whether this compression technique could be an easy, low-cost way to help stroke survivors recover more muscle function and endurance.
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If you are a stroke survivor, you would visit the laboratory 6 times over several weeks. During each visit, researchers will measure blood flow in your legs while you do gentle leg exercises, and they may wrap a blood pressure cuff around your leg and inflate it to briefly pause blood flow (this is painless). You'll also be randomly assigned to receive either the real compression treatment or a sham version (where the cuff is inflated very lightly). If you are a healthy control participant, you would visit 3 times for similar but shorter testing to help researchers compare your results to stroke survivors' results.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
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