Plain-English translation of NCT06033131 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
Preeclampsia is a serious condition in pregnancy that causes dangerously high blood pressure and requires early delivery, which can harm the baby. This trial is testing whether metformin—a medication commonly used to treat diabetes—might help pregnant women with this condition stay pregnant longer and have healthier babies. Earlier research showed promising results, and this larger study aims to confirm whether this approach works in Nordic countries.
When preeclampsia develops early in pregnancy, doctors must deliver the baby early to protect the mother's health, but premature birth causes serious complications for newborns. Researchers believe this medication may help manage the disease and allow pregnancies to continue safely longer, reducing the need for emergency early delivery.
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You would be randomly assigned to take either the medication or a placebo (dummy pill) three times daily, starting with one tablet and increasing to two tablets as tolerated. You would continue this treatment while your pregnancy is monitored with regular clinic visits and tests. The study follows you and your baby after birth to track outcomes like how long your baby stays in the hospital and birth weight.
AI-generated summary from trial data · Jul 13, 2026 · Not medical advice
Finland
Norway
Sweden