Plain-English translation of NCT06038630 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This research study is testing a new type of MRI scan called 129Xe gas exchange MRI that can show how well your lungs are working and how oxygen gets into your red blood cells. Instead of using radiation like a CT scan, this MRI uses a special type of gas that helps doctors see your lung function in a new way. The study includes healthy volunteers and people with various lung and heart conditions.
Current imaging tests don't always show exactly how well a person's lungs are exchanging oxygen with the bloodstream, especially in people with conditions like pulmonary fibrosis, blood clots in the lungs, or chronic shortness of breath. This trial is testing whether this new MRI method can provide doctors with better information to diagnose and monitor these serious conditions.
You likely qualify if…
You likely don't qualify if…
You will come to the hospital or clinic to receive the specialized MRI scan, which involves breathing in a special gas while lying in the MRI machine—similar to a standard MRI but using gas instead of radiation. Depending on which group you join, you may have scans before and after a medical treatment (like blood transfusion, oxygen therapy, or lung surgery), and some participants may be asked to return 3–6 months later for follow-up scans to see how their condition has changed.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
Bastiaan Driehuys
Collaborators
National Institutes of Health (NIH)
Enrollment target
~125 participants
Started
January 2024
Primary completion
June 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
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Central contact
Bastiaan Driehuys, PhD
Duke University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.