Plain-English translation of NCT06041204 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether letrozole—a medication that helps trigger ovulation—works better when combined with levothyroxine, a thyroid medication. The study involves women who have both PCOS (polycystic ovary syndrome) and subclinical hypothyroidism (a mild thyroid condition). Researchers want to see if treating both conditions together leads to better chances of ovulation and pregnancy compared to treating only PCOS.
Many women with PCOS struggle to become pregnant because they don't ovulate regularly. Recent evidence suggests that a mild thyroid condition may make this problem worse, but it's unclear whether treating the thyroid at the same time as the ovulation problem improves results. This trial aims to answer that question.
You likely qualify if…
You likely don't qualify if…
If you join this study, you'll be randomly assigned to one of two groups. Both groups will take letrozole (a fertility medication) for 5 days starting on day 3 of your menstrual cycle, with doses adjusted based on how your body responds. One group will take letrozole alone, while the other will also take a daily thyroid medication. You'll have regular ultrasounds and blood tests to check for ovulation, and the study will continue for up to 6 months or until you become pregnant. Throughout, your doctor will monitor you for any side effects and provide standard prenatal care if you do conceive.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Egypt