Plain-English translation of NCT06044935 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research trial is investigating whether nicotinamide riboside, a naturally occurring B vitamin, can help your body burn more fat and use energy more efficiently when you follow a ketogenic (low-carbohydrate) diet. Researchers want to understand how this medication affects your metabolism, especially while you sleep. The study will compare people taking the supplement to those taking a placebo (an inactive pill) to see if there are real differences.
Scientists are interested in finding ways to help people with overweight and obesity improve their metabolism and fat-burning capacity. This treatment might offer a way to enhance the metabolic benefits of a ketogenic diet, but first they need to test whether it actually works and is safe.
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You would first follow a normal, high-carbohydrate diet while researchers measure your baseline metabolism. Then you would switch to a ketogenic (low-carbohydrate) diet for several weeks while taking either the nicotinamide riboside supplement or a placebo. Throughout the study, you'll have overnight sleep sessions where researchers measure how much energy you burn and how much fat your body is using. You'll also complete blood tests, keep track of what you eat, and provide information about your sleep, hunger, and physical activity. The entire study typically lasts several weeks, with multiple clinic visits.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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