Plain-English translation of NCT06048172 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Post Traumatic Stress Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether a type of talk therapy called Prolonged Exposure can help reduce symptoms of PTSD and psychosis in people who experience both conditions together. Usually, people with psychosis are thought to be too unwell to do this kind of trauma-focused therapy, but researchers want to see if it's safe and effective anyway. You would either receive the therapy right away or wait 14 weeks before starting.
Many people experience both psychotic symptoms and trauma-related stress, but there hasn't been much research on whether trauma-focused therapy works for them. Doctors often avoid this treatment in people with psychosis because they worry it might make symptoms worse—this study aims to find out if that concern is valid, or if people with both conditions can actually benefit.
You likely qualify if…
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If you are selected, you will be randomly placed into either the therapy group or a waiting group. If you are in the therapy group, you will receive 16 one-on-one therapy sessions (about 1–2 per week for 7–16 weeks) focused on helping you process your trauma memories. Some sessions will be recorded so you can listen to parts at home as homework. You will complete questionnaires at the start, after therapy ends, and 6 months later to track your progress.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Germany
Sponsor
Medicalschool Hamburg
Collaborators
Psychiatrische Klinik Lüneburg, Regioklinikum Elmshorn
Enrollment target
~56 participants
Started
May 2023
Primary completion
May 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Susanne Sarkar, Dr.
Medicalschool Hamburg
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.