Recruiting

Two ways to treat early-stage lung cancer with heat ablation

Plain-English translation of NCT06052098 on ClinicalTrials.gov ↗ · Source last updated December 2023 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing two different ways to treat early-stage lung cancer using radiofrequency ablation (RFA), a technique that uses heat to destroy cancer cells. One approach uses a thin camera passed down your throat (bronchoscopy-guided), while the other uses imaging scans to guide a needle through your skin (CT-guided). The study will compare which method works better at completely eliminating the cancer and which is safer.

For people with early-stage lung cancer who cannot have surgery or prefer not to have it, there is a need to find the safest and most effective way to treat the cancer. This trial exists to determine which of these two minimally invasive heat-based approaches gives patients the best chance of eliminating their cancer with the fewest side effects.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have been diagnosed with stage IA lung cancer (early-stage peripheral lung cancer) confirmed by biopsy
you are unable to have surgery or have chosen not to have surgery for your lung cancer
your cancer is in a location that can be treated with either of these two ablation methods
you are willing to receive ablation therapy and commit to follow-up appointments for monitoring

You likely don't qualify if…

you have a bleeding disorder or very low platelet count that cannot be quickly fixed
you have severe lung scarring or high blood pressure in your lungs
you have an active infection or fever (over 38.5°C) that is not well controlled
you have a pacemaker, defibrillator, or other implanted electronic device
you are pregnant, planning to become pregnant during the study, or have stopped blood-thinning medications less than 5–7 days before the procedure

What participation looks like

If you join this study, you will be randomly assigned to receive either the bronchoscopy-guided or CT-guided heat ablation treatment. After your treatment, you will have follow-up imaging scans and appointments to check how well the cancer was destroyed — at 6 months, 12 months, and then at 1, 2, and 3 years after your procedure. The research team will monitor you for any side effects and track how well the treatment is working to control your cancer.

AI-generated summary from trial data · Aug 8, 2026 · Not medical advice

Trial locations(1 site)

China

Shanghai Chest Hospital, Shanghai, Shanghai Municipality