Testing a water pill to slow memory loss in early Alzheimer's disease

This trial is testing bumetanide, a medication already approved and used for high blood pressure and fluid buildup, to see if it might help people with early Alzheimer's disease. Researchers noticed that people over 65 who took this medication seemed to have lower rates of Alzheimer's, so they want to study whether it actually works and is safe for this new purpose. You would take either the medication at a low dose, a high dose, or a placebo (a pill with no medicine) for 6 months while doctors monitor your thinking, memory, and blood markers.

Most current Alzheimer's treatments only address symptoms briefly, and there is a pressing need for new approaches that might slow the disease itself. This medication shows promise in laboratory studies and health records, so this trial will test whether it's truly safe and effective in people with early memory problems.