Plain-English translation of NCT06053580 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether valsartan, an existing medication commonly used for blood pressure and heart failure, might help protect and strengthen the right side of your heart when it's under stress from pulmonary arterial hypertension. Early research suggests it may work, but doctors need to confirm this with a proper clinical trial. You would take either valsartan or a placebo (inactive pill) twice daily for 24 weeks.
Right-sided heart problems from pulmonary arterial hypertension can lead to heart failure, but unlike left-sided heart failure, there are currently no medications designed specifically to help the right heart function better. This trial aims to fill that gap by testing whether this medication might protect and strengthen the right heart.
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You would visit the clinic at weeks 0, 2, 12, and 24 — each visit adding 20–30 minutes to your standard care. You'll take a capsule twice daily for 24 weeks (either the active medication or placebo). You'll have heart ultrasounds (echocardiograms) at the beginning and end of the study, and the visits at weeks 2 and 12 can usually be done remotely. Some participants may optionally choose additional heart tests like exercise testing or a right heart catheterization, but these are not required.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
University of Washington
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~60 participants
Started
February 2024
Primary completion
July 2027
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Laurie Hogl, RRT
University of Washington
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.