Recruiting

Two breathing support methods for babies with bronchiolitis

Plain-English translation of NCT06053684 on ClinicalTrials.gov ↗ · Source last updated September 2025 · Translation generated September 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

Bronchiolitis is a viral infection that affects the small airways in babies' lungs, making it hard for them to breathe. This trial is testing whether a newer breathing support method called Neurally-Adjusted Ventilatory Assistance (NAVA) works better than standard breathing support for babies in the ICU with severe bronchiolitis. Both methods use a gentle mask or nasal tube to deliver oxygen and help the baby's lungs work less hard, but NAVA is designed to respond more closely to the baby's own breathing efforts.

Standard breathing support for bronchiolitis works well for many babies, but doctors are exploring whether NAVA—a method that syncs more precisely with a baby's natural breathing rhythm—might lead to faster recovery, fewer complications, or less need for more invasive treatment.

Do you qualify?

You likely qualify if…

your child is under 2 years old
your child has been diagnosed with bronchiolitis
your child's doctor believes both breathing support methods could work equally well for them
your child can have a feeding tube placed through the nose (required for NAVA monitoring)

You likely don't qualify if…

your child cannot have a nasogastric (feeding) tube
your child has chronic lung disease, a cyanotic heart condition, or heart failure
your child has low muscle tone (hypotonia)
your child needs very high oxygen levels or is likely to need immediate intubation
your child is hemodynamically unstable or requiring blood pressure support medications

What participation looks like

If your child is enrolled, they will receive one of the two breathing support methods while hospitalized in the ICU. One group receives standard non-invasive ventilation, while the other receives the NAVA method. Both use a specialized nasal mask or tube to deliver oxygen and support breathing without needing a tube down the windpipe. Your child will be monitored closely with standard ICU care, and the research team will track how well each method works and whether your child recovers more quickly.

AI-generated summary from trial data · Sep 11, 2026 · Not medical advice

Trial locations(1 site)

United States

Children's Hospital at Montefiore, The Bronx, New York