Plain-English translation of NCT06054295 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a research study for twins where one twin has been diagnosed with a brain or spinal cord tumor and the other twin has not. Researchers will collect small samples of blood and saliva from both twins to look at their genes and understand what genetic differences might explain why one twin developed cancer and the other did not. This information could help doctors better understand and prevent childhood brain tumors in the future.
Identical twins share the same genes, but sometimes only one twin develops cancer. By studying twins where one has a brain tumor and one does not, researchers hope to discover which genetic changes in cells might lead to cancer development — and this could lead to better ways to detect and prevent these tumors.
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If you and your twin join this study, you will each provide small samples of blood and saliva — a simple, painless process similar to a regular blood test and a saliva collection. These samples will be sent to a lab where researchers will study your genes to look for differences that might explain why one twin developed a brain tumor and the other did not. The study takes place at the time you enroll, though researchers may also look at blood samples taken before and after any cancer treatment you received.
AI-generated summary from trial data · Sep 5, 2026 · Not medical advice
United States
Sponsor
Children's Oncology Group
Collaborators
National Cancer Institute (NCI)
Enrollment target
~50 participants
Started
June 2024
Primary completion
June 2027
Last updated on clinicaltrials.gov in October 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jenny Poynter, PhD
University of Minnesota
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.