Plain-English translation of NCT06054633 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether L-arginine, an amino acid that your body naturally produces, can help relieve pain from knee osteoarthritis. Researchers have noticed that people with knee arthritis often have lower levels of this amino acid, and early studies suggest it may help reduce pain. This study will compare the medication to a placebo (a dummy pill) to see if it really works and is safe.
Knee osteoarthritis causes significant pain, and the medications doctors typically prescribe (like NSAIDs) can have serious side effects on the heart and stomach. This trial exists because researchers need to find safer, effective options for managing arthritis pain, and preliminary evidence suggests this natural supplement might be a promising candidate.
You likely qualify if…
You likely don't qualify if…
If you qualify and enroll, you will be randomly assigned to take either the L-arginine supplement or a placebo pill three times daily. You will not know which one you are taking—this is called a 'blinded' study, which helps ensure fair results. You will attend study visits where your pain and symptoms are measured, and your safety is monitored through blood tests and check-ins.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
China
Sponsor
Xiangya Hospital of Central South University
Collaborators
Massachusetts General Hospital, School of Medicine, University of Nottingham
Enrollment target
~340 participants
Started
March 2024
Primary completion
September 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
40 Years – 80 Years
Last updated on clinicaltrials.gov in June 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Yilun Wang, MD, PhD
Xiangya Hospital of Central South University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.