Recruiting

Testing a new medicine for low white blood cell disorders with repeated infections

Plain-English translation of NCT06056297 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This study is testing a new medication called to help people who have chronic low white blood cell counts (a condition called neutropenia) and keep getting serious or repeated infections. The medication is taken as a pill once a day for a year. You'll continue any other treatments you're already using while participating.

People with chronic low white blood cell counts are especially prone to serious infections that can be hard to treat and affect their quality of life. This trial is trying to see if this new treatment can help reduce how often these infections happen, even in patients who are already on other therapies.

Do you qualify?

You likely qualify if…

you have been diagnosed with a chronic low white blood cell disorder (inherited or acquired) for at least 6 months before joining
you have experienced at least 2 serious or repeated infections in the past 12 months that required antibiotics or a hospital or urgent care visit
your white blood cell count is below 1,000 cells per microliter when you are screened and confirmed at baseline
you are willing to keep any current treatments (such as G-CSF injections or antibiotics) at a stable dose throughout the study

You likely don't qualify if…

your low white blood cell count is caused by another disease like lupus, rheumatoid arthritis, or inflammatory bowel disease
your low white blood cell count is caused by medications you are taking (such as chemotherapy), infections, or nutritional deficiencies
your low white blood cell count is caused by an enlarged spleen, cancer, or other secondary conditions
you have a current systemic infection at the time of screening

What participation looks like

You will take the medication (or placebo) as a pill once every day for 52 weeks while continuing any other treatments you currently use. You'll have regular visits to the study site for blood tests to monitor your white blood cell counts and check for infections. Some participants will receive the actual new medication, while others will receive a placebo (inactive pill), though researchers will work to keep this fair.

AI-generated summary from trial data · Aug 7, 2026 · Not medical advice

Trial locations(114 sites)

United States

Phoenix Children's Hospital, Phoenix, Arizona

UC Irvine, Irvine, California

Orso Health, La Jolla, California

University of California, Los Angeles-UCLA, Los Angeles, California

Orso Health, Torrance, California