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Using MRI to track lung changes in cystic fibrosis over one year

Plain-English translation of NCT06057714 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

Read our Cystic Fibrosis research guide →

What is this trial?

Researchers want to better understand how cystic fibrosis affects the lungs by using a special type of MRI imaging called functional MRI with an inhaled contrast gas. This new imaging approach may help doctors see changes in lung function more clearly than current tests. The study will follow you for one year and compare this new imaging method to standard lung function tests.

Current ways of measuring lung function in cystic fibrosis patients have limitations. This research aims to develop a more detailed imaging method that can detect subtle changes in how air moves through the lungs, potentially helping doctors catch problems earlier and track how treatments are working.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with cystic fibrosis
your lung function is relatively mild to stable (FEV1 at least 60% of predicted)
you do not use supplemental oxygen
you have not had a pulmonary exacerbation (flare-up) in the past 4 weeks

You likely don't qualify if…

you have smoked or vaped in the past year, or have a significant smoking history
you have metal implants or devices in your body that are not MRI-safe (such as pacemakers, aneurysm clips, or certain pumps)
you have significant facial hair that cannot be removed or claustrophobia that would prevent you from undergoing an MRI
you have changed CF medications in the past month or are using experimental therapies
you are pregnant or unable to tolerate inhaling a gas mixture

What participation looks like

You would visit the University of North Carolina at Chapel Hill for 3 to 5 visits over one year, depending on whether you experience a lung exacerbation. Each visit lasts up to 4 hours and includes breathing in a harmless inhaled contrast gas while undergoing an MRI scan, plus standard lung function tests. If you have a lung exacerbation during the study, you would have additional visits before and after treatment to see how the imaging changes.

AI-generated summary from trial data · Jul 5, 2026 · Not medical advice

Using MRI to track lung changes in cystic fibrosis over one year

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)