Testing a New Drug to Treat Brain Tumors

This trial is testing a drug called trastuzumab deruxtecan (T-DXd) to see if it can travel through the body into brain tumors and help treat them. The study focuses on people with brain cancer or cancer that has spread to the brain, particularly those whose tumors have a specific protein or genetic change called HER2. Researchers want to understand how well this medication can penetrate brain tumors and whether it can be an effective treatment option.

Brain tumors are very difficult to treat because many medications cannot easily cross the protective barrier around the brain. This trial exists to see whether this medication can overcome that barrier and reach brain tumors effectively, potentially offering hope to people with advanced brain cancer who have limited treatment options.