Testing two medications combined with chemotherapy for newly diagnosed blood cancer

Plain-English translation of NCT06061094 on ClinicalTrials.gov ↗ · Source last updated April 2025 · Translation generated July 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing whether , a newer targeted medication, works better than (the current standard) when combined with low-dose chemotherapy for a specific type of blood cancer called Philadelphia chromosome–positive acute lymphoblastic leukemia in adults. The study also tests whether adding a medication called can help patients avoid or delay a stem cell transplant if they respond well to initial treatment. You would be randomly assigned to receive either the standard or newer medication, and your response to treatment would determine what additional medications you receive.

Currently, patients with this type of blood cancer receive combined with chemotherapy, but some patients do not respond well enough and need a stem cell transplant. Researchers want to know if (a stronger medication) or (a different type of drug) could help more patients avoid this intensive procedure or improve their chances of survival.

Do you qualify?

You likely qualify if…

you are between 18 and 65 years old
you have been newly diagnosed with Philadelphia chromosome–positive acute lymphoblastic leukemia
you have received only minimal prior treatment (such as steroids or a single dose of standard pre-treatment)
you have a performance status that allows you to carry out most daily activities (ECOG score of 2 or better)
you are willing to use effective contraception during and for 3 months after treatment (if you are a woman or man with a female partner of childbearing potential)

You likely don't qualify if…

you have had another cancer diagnosed within the past 5 years (with limited exceptions)
you have previously taken tyrosine kinase inhibitor medications
you have serious heart disease, a history of stroke, or uncontrolled high blood pressure
you have HIV, active Hepatitis B or C, or a recent history of pancreatitis
you are pregnant, nursing, or unable to use reliable contraception

What participation looks like

You would receive either or as a daily oral medication, combined with low-dose chemotherapy given according to a treatment schedule. After an initial phase, your cancer response would be measured, and depending on your results, you might continue with additional medications including or move toward a stem cell transplant. You would attend regular clinic visits for blood tests, heart monitoring, and physical exams throughout your treatment, which typically spans several months.

AI-generated summary from trial data · Jul 15, 2026 · Not medical advice

Testing two medications combined with chemotherapy for newly diagnosed blood cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations