Testing personalized dosing of an immune-boosting cancer drug

Plain-English translation of NCT06066138 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

What is this trial?

This trial is testing a new approach to dosing , a medication that helps the immune system fight several types of advanced cancer. Instead of using standard fixed doses for everyone, researchers want to see if they can personalize doses based on each patient's blood drug levels—potentially reducing side effects while keeping the treatment effective.

Current standard doses of this medication are much higher than the minimum amount needed to fight cancer, which was done to ensure all patients get enough even if their bodies process the drug differently. This trial wants to see if careful blood monitoring could allow for lower, personalized doses that are still effective but potentially cause fewer side effects.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with advanced or locally advanced cancer (including lung cancer, liver cancer, melanoma, or alveolar soft part sarcoma) that your doctor believes will respond to this medication
you are in good enough overall health to receive this treatment (ECOG performance status 0–2)
your blood counts and organ function (liver, kidney, bone marrow) are adequate based on recent lab work
you are willing to use effective birth control during treatment and for 5 months after your last dose if you can become pregnant or father children

You likely don't qualify if…

you have untreated brain metastases or brain cancer that is still progressing
you have HIV, hepatitis B, or hepatitis C infection that is not well controlled with medication
you are unable to have adequate organ and bone marrow function, or have severely abnormal liver or kidney tests
you are pregnant, nursing, or unwilling to use birth control during the study and for 5 months after treatment ends

What participation looks like

You will receive as an intravenous infusion over 16 weeks. Throughout the study, your medical team will draw blood samples to measure how much medication is in your system and adjust your dose based on those results to keep levels in an effective range. You'll have regular clinic visits, lab tests, and imaging scans to monitor how you're responding to treatment and watch for any side effects.

Testing personalized dosing of an immune-boosting cancer drug

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)