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Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing fecal microbiota transplantation (FMT) — a procedure where healthy bacteria from a donor are transferred into your gut — to treat people with ulcerative colitis who keep getting C. difficile infections. The study compares two approaches: receiving this treatment once versus receiving it multiple times over a period. The goal is to see which approach works better at stopping the infections and improving your ulcerative colitis symptoms.
People with ulcerative colitis are much more likely to develop recurring C. difficile infections, and these infections can be serious and hard to treat with antibiotics alone. Early evidence suggests that restoring healthy gut bacteria through this treatment may be more effective than current options, especially when given multiple times rather than just once.
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If you enroll, you will be randomly assigned to receive either one infusion of healthy donor bacteria or multiple infusions spaced over time. The procedure itself involves introducing the donor bacteria into your colon through colonoscopy or another method. You will have follow-up visits to monitor whether the C. difficile infection returns and whether your ulcerative colitis improves, allowing researchers to compare which approach works better for you.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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