Plain-English translation of NCT06077747 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a procedure called lumbar vein embolization—a minimally invasive treatment where doctors insert a thin tube into a vein in your lower back and place small coils to block abnormal blood flow. The procedure targets people with chronic daily headaches caused by a specific condition called Nutcracker syndrome, where compressed blood vessels create unusual pressure in the spinal area. The goal is to see if blocking this problematic vein can reduce or stop the headaches.
Chronic daily headaches caused by Nutcracker syndrome can be extremely difficult to treat with standard medications. Many patients who have tried multiple preventive drugs without relief may benefit from this new procedure that targets the underlying blood vessel problem rather than just treating symptoms.
You likely qualify if…
You likely don't qualify if…
First, a headache specialist and eye doctor will evaluate you in detail, including special eye exams and blood tests. Then you will have an MRI scan to confirm you have the specific vein problem this trial treats. If you qualify, you will undergo the vein-blocking procedure, which involves a catheter inserted through a small puncture—similar to an angiogram. After the procedure, you will have follow-up visits to monitor how your headaches respond to the treatment.
AI-generated summary from trial data · Jul 11, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~4 participants
Started
September 2024
Primary completion
September 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in November 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Julia Santos
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.