Plain-English translation of NCT06080646 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →Researchers want to understand how depression changes the way your brain processes rewards — things that normally bring pleasure or motivation. By using brain imaging (fMRI) and electrical recordings (EEG), they hope to identify different patterns in how people with depression experience pleasure and make decisions, and how these patterns might relate to suicide risk.
Many people with depression lose interest in activities they once enjoyed and feel unmotivated. This study aims to understand the brain changes behind these symptoms so doctors can eventually identify who needs which treatments and better predict who may be at higher risk.
You'll visit the research lab in San Francisco for sessions where you'll complete brain imaging scans (fMRI) and wear electrodes to record brain electrical activity (EEG) while performing tasks related to reward and decision-making. The study is observational, meaning researchers are watching and measuring your brain's responses rather than giving you a new medication to test. Sessions may take several hours, but the specific number of visits and total time commitment should be discussed with the research team.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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