Plain-English translation of NCT06081426 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Bipolar Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are investigating whether a ketogenic diet—a high-fat, low-carbohydrate eating plan—might help reduce mania and mood swings in people with bipolar disorder. The study uses advanced brain imaging and blood tests to understand how this diet affects the brain's chemistry and function. By comparing people with bipolar disorder to healthy volunteers, the researchers hope to discover the biological mechanisms that make this dietary approach potentially beneficial.
Current bipolar disorder treatments don't work equally well for everyone, and some people experience significant side effects. This research explores whether a dietary change could offer a new or complementary treatment option by examining how it affects brain metabolism and reduces the severity of manic episodes.
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Participants in the diet groups will follow either a normal diet or a ketogenic diet for one phase, then switch to the other diet for a second phase. During the study, you'll have brain imaging scans, blood tests to measure how your body is responding, and may provide a small skin sample for research on your cells. The whole study lasts several weeks, with regular check-ins to monitor your mood and health. Healthy volunteers without bipolar disorder will complete the brain scans and blood tests but will not follow the special diets.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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