Plain-English translation of NCT06085781 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are studying how head and neck squamous cell carcinoma changes during treatment by combining special MRI scans with tumor tissue samples. The study will also use a medication called pimonidazole to help identify areas in the tumor that don't get enough oxygen. This research aims to better understand what happens inside tumors as they respond to radiation or surgery.
Doctors want to learn more about how tumors change during treatment so they can eventually predict which patients will respond well to therapy and which ones might need different approaches.
You likely qualify if…
You likely don't qualify if…
If you receive radiation therapy, you'll have an MRI scan and a small tumor biopsy before treatment starts, then again during week 2 of your radiation course—and possibly again in week 4 if you're tolerating treatment well. If you're having surgery, you'll have an MRI scan within a week before your operation, and tumor tissue will be collected during surgery. Before each biopsy or surgery, you'll take a medication by mouth the night before to help researchers see which parts of your tumor lack oxygen.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
Canada
Sponsor
University Health Network, Toronto
Enrollment target
~60 participants
Started
January 2024
Primary completion
January 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Andrew McPartlin
University Health Network, Toronto
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.