Plain-English translation of NCT06088381 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new approach to treating HPV-positive throat cancer. Instead of giving all patients radiation or chemotherapy after surgery, doctors will use a blood test that detects leftover cancer cells to decide who really needs additional treatment. The goal is to avoid unnecessary side effects while keeping cure rates high.
Most patients with HPV-positive throat cancer survive well, but the radiation and chemotherapy used to treat it can cause serious long-term side effects. This trial exists to find out whether we can safely give less treatment to patients whose blood tests show no cancer remaining after surgery.
You likely qualify if…
You likely don't qualify if…
You will have throat cancer surgery performed by the study team. After surgery, doctors will check a blood sample to see if cancer cells are still present. If the blood test is negative, you will enter the observation phase and be monitored closely with physical exams, imaging, and periodic blood tests instead of receiving radiation or chemotherapy. If cancer signs appear, the team will discuss treatment options with you. The study involves regular visits to the hospital over several years for monitoring and quality-of-life assessments.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States