Plain-English translation of NCT06088732 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
Researchers want to understand whether a single session of moderate exercise can help reduce depression symptoms in people with bipolar disorder, and whether taking ibuprofen during exercise changes how well it works. This study will compare exercise to rest, and test each condition both with and without ibuprofen, to learn how the medication might interfere with or enhance exercise's benefits on mood and brain activity.
Depression in bipolar disorder is hard to treat, and current medications don't work for everyone. Exercise is known to help mood in some people, but researchers don't fully understand why—or whether blocking the body's normal inflammatory response to exercise (which is what ibuprofen does) might actually get in the way of its mood-boosting effects.
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You will complete four separate study sessions, each involving either 30 minutes of moderate-intensity cycling or 30 minutes of sitting at rest, paired with either a single dose of ibuprofen or a placebo pill. Between sessions, researchers will measure your mood, take blood samples to check inflammation, and use brain imaging (MRI) to see how your brain responds to each condition. The study is designed so that you experience all four combinations in a balanced order, which helps researchers figure out whether exercise, the medication, or both together make a difference.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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