Plain-English translation of NCT06095128 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing whether two medications called and work better when given together to treat moderate to severe ulcerative colitis. The trial will enroll about 65 people and last up to 76 weeks. If the medication combination works well for you after 8 weeks, you'll continue with one of the medications alone for several more months.
Many people with ulcerative colitis don't respond well enough to current treatments, or their symptoms come back after initial improvement. This trial is testing whether combining these two medications in a new way might help people whose disease has not been controlled by previous treatments.
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You'll receive intravenous infusions of one medication at weeks 0, 2, and 6, while taking a tablet of the other medication twice daily for the first 8 weeks. After 8 weeks, if your symptoms improve, you'll continue with infusions every 8 weeks for about 44 more weeks. The entire study lasts up to 76 weeks, and you'll be followed for an additional 26 weeks after finishing the medications for safety monitoring. Visits will take place at multiple research centers across the United States and Canada.
AI-generated summary from trial data · Jul 13, 2026 · Not medical advice
United States