Plain-English translation of NCT06096675 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a structured, supervised exercise program can help people with cardiac amyloidosis—a condition where abnormal proteins build up in the heart—feel stronger and improve their heart's performance. Half of the participants will join a guided exercise program, while the other half will receive standard care, so researchers can fairly measure whether the exercise program makes a real difference.
Right now, insurance often doesn't cover rehabilitation programs for people with cardiac amyloidosis, even though exercise might help them. This study aims to prove that supervised exercise really works for these patients, which could eventually convince insurance companies to cover this treatment and help many more people with heart conditions.
You likely qualify if…
You likely don't qualify if…
If you're in the exercise group, you'll start with two fitness tests—a six-minute walk test and a cardiopulmonary exercise test—to measure your baseline fitness and heart function. Then you'll attend three one-hour supervised exercise sessions each week for 12 weeks (36 sessions total) at the cardiac rehabilitation program. After the 12 weeks are done, you'll repeat the two fitness tests to see how much you've improved. If you're in the comparison group, you'll have the same fitness tests at the beginning and again 12–14 weeks later, but without the exercise program in between.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
United States
Sponsor
Wake Forest University Health Sciences
Enrollment target
~50 participants
Started
January 2024
Primary completion
December 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Dana B Amaro, RN
Wake Forest University Health Sciences
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.