Recruiting

Testing a Specialized Diet to Prevent Stroke in High-Risk Adults

Plain-English translation of NCT06098235 on ClinicalTrials.gov ↗ · Source last updated June 2025 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a new eating plan called the ORIENT diet, designed specifically to protect your brain and reduce your stroke risk. The diet combines proven heart-healthy eating patterns from Mediterranean and Asian cuisines and is tailored to foods commonly eaten in Asian cultures. Researchers want to see if following this diet for 6 months can improve how your brain functions and protect you from stroke.

Many people have multiple conditions or habits that put them at high risk for stroke, but standard dietary advice may not be enough to prevent it. This treatment combines the best-studied healthy eating approaches in a way that matches Asian food traditions, making it easier for people in those communities to follow long-term.

Do you qualify?

You likely qualify if…

you are 40 years old or older
you have had a mini-stroke (transient ischemic attack) or have at least 3 stroke risk factors such as high blood pressure, high cholesterol, diabetes, irregular heartbeat, smoking, overweight, lack of exercise, or family history of stroke
you do not have dementia or memory problems
you can see and hear well enough to complete memory and thinking tests
you are willing to follow a new eating plan and complete study visits over 2 years

You likely don't qualify if…

you have allergies to nuts, berries, olive oil, or fish
you have been diagnosed with dementia or memory loss
you have had major head trauma or brain surgery in the past
you have a serious illness expected to shorten your life to less than 3 years
you cannot have an MRI scan for medical reasons

What participation looks like

If you join, you will be randomly assigned to either follow the new ORIENT diet or receive standard low-sodium, low-fat dietary advice. Over 2 years, you will visit the clinic at the start, at 6 months, and at 2 years for check-ups that include memory and thinking tests, blood and stool samples, and brain imaging scans. The main goal is to see whether the specialized diet helps protect your brain's function and reduces your stroke risk over time.

AI-generated summary from trial data · Aug 6, 2026 · Not medical advice

Trial locations(1 site)

China

Second Affilated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang