Personalized treatment approach based on fitness level in older myeloma patients

This study is testing a new approach called dynamic frailty-tailored therapy for older adults with newly diagnosed multiple myeloma. Instead of giving all patients the same treatment plan, doctors will assess how physically fit you are at the start and then adjust your treatment throughout your care based on how your fitness changes. The goal is to find the right balance between fighting the cancer effectively and keeping side effects manageable.

Older patients with multiple myeloma vary widely in their physical strength and ability to tolerate intensive treatments. Some patients are very frail and struggle with harsh side effects, while others are quite fit and can handle more intensive therapy. Currently, doctors typically check fitness only once at diagnosis, but research shows that fitness changes over time as patients age and undergo treatment. This trial exists to see whether checking and adjusting treatment based on fitness throughout the treatment course—rather than just at the beginning—leads to better outcomes.