Adding targeted radiation or heat treatment to cancer therapy for spreading tumors

This trial is testing whether adding locally ablative therapies—special targeted treatments that use radiation or heat to destroy tumors—alongside your current cancer medications can help keep your cancer under control. The study focuses on people whose cancer is spreading despite being on systemic therapy (medications taken throughout the body). Researchers want to see if combining both approaches works better than medication alone.

When cancers start spreading to new areas despite treatment, doctors often have limited options. This trial explores whether targeting just the new or worsening tumors with focused radiation or heat—while continuing your current medications—could help extend the time your cancer stays stable and delay the need to switch to different drugs.