Plain-English translation of NCT06105710 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Asthma research guide →Researchers at UCSF are trying to understand why some people with asthma develop severe, life-threatening airway blockages caused by excess mucus. This study involves collecting small tissue samples from your airways using a procedure called bronchoscopy to examine how immune cells and proteins change the way your airway cells produce and release mucus.
Severe asthma can be life-threatening, especially when mucus plugs block the airways. Current treatments don't work well for everyone, so researchers need to understand the exact biological mechanisms causing this mucus buildup so they can develop better, more targeted treatments in the future.
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You will visit the UCSF Airway Clinical Research Center for a bronchoscopy procedure, during which doctors pass a thin tube down your throat to collect small tissue samples from your airways. You'll need to stop taking certain asthma and allergy medications before your visit and before the procedure. The study involves comparing airway tissue from people with asthma to tissue from healthy volunteers to identify the biological differences that cause severe asthma.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States
Sponsor
University of California, San Francisco
Collaborators
National Institute of Allergy and Infectious Diseases (NIAID)
Enrollment target
~24 participants
Started
July 2024
Primary completion
December 2027
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Christine P Nguyen, BS
University of California, San Francisco
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.