Receive two different types of breathing support to compare their effects

Back to to Assess the Corresponding PEEP Values in NIV With CPAP Under Different Airflow Rates During HFOT in Heart Failure Patients trials

What is this trial?

This study is testing whether high-flow oxygen therapy (a newer breathing support method that delivers oxygen at high rates through the nose) works similarly to non-invasive ventilation (a mask-based breathing support) in heart failure patients. Researchers want to understand how much pressure each method creates in your lungs and whether they have similar effects on helping you breathe.

While non-invasive ventilation has been used successfully in heart failure patients for years, it can be uncomfortable or unsuitable for some people. High-flow oxygen therapy is newer, often more comfortable, and may provide similar benefits—but doctors don't yet fully understand how the pressure it creates compares to traditional non-invasive ventilation.

Do you qualify?

You likely qualify if…

you are admitted to an ICU with heart failure and low oxygen levels requiring breathing support
you have been stable on both high-flow oxygen therapy and non-invasive ventilation for at least 24 hours
you are alert and able to follow instructions
you have lung infiltrates (fluid or inflammation) visible on a recent chest X-ray
you are 18 years old or older

You likely don't qualify if…

you have had a tracheostomy (a surgically created breathing hole in your neck)
you have severe COPD (a lung disease that severely limits airflow)
you have nasal trauma, a deviated septum, or other nasal problems that prevent using high-flow oxygen
you have facial wounds or other conditions preventing use of a breathing mask
you have a pacemaker or other implanted device that would interfere with the electrical measurement equipment

What participation looks like

You will be randomly assigned to one of two groups. Your group determines the order in which you try different breathing support settings. You'll receive an oxygen mask, then try high-flow oxygen therapy at three different flow rates (40, 50, and 60 liters per minute) or non-invasive ventilation at three different pressure settings—spending about 5–10 minutes with each setting. Throughout, researchers will monitor your heart rate, blood pressure, oxygen levels, and breathing using a special belt that measures how air moves in your lungs. The entire session lasts about an hour, and you'll remain in the ICU during this time.

Comparing two breathing support methods in heart failure patients

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)