Plain-English translation of NCT06108076 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Type 2 Diabetes research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a medication called ketone ester to see if it can help people who have both heart failure (where the heart doesn't pump as strongly as it should) and type 2 diabetes. Researchers want to understand how the medication affects your heart function and blood sugar control by measuring changes during heart imaging scans and blood tests. The goal is to see if this treatment might offer a new way to help manage both conditions together.
People with weakened heart function and diabetes often struggle to manage both conditions with current treatments, and some common diabetes medications can actually make heart problems worse. Researchers believe this medication might help the heart work more efficiently while also improving blood sugar control, potentially offering a better treatment option for people facing both challenges.
You likely qualify if…
You likely don't qualify if…
You would visit the research center four times over about a week. At your first main visit, you'd take two doses of the medication by mouth while your heart is being scanned with an MRI machine, and researchers would draw blood samples every 30 minutes to track how the medication affects your body. You'd return the next day for another MRI and blood draw, then take the medication at home once daily for the next several days before a final visit with an MRI and blood work around day 7. In total, you'd have several heart imaging scans and eight blood draws to help researchers understand how the treatment works.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States