Plain-English translation of NCT06109467 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a medication called , given together with three other proven cancer treatments: chemotherapy, , and . The goal is to see whether this four-drug combination works better and is safe for people with stomach or esophageal cancer that has a specific genetic marker called HER2 overexpression. Researchers want to understand both the benefits and side effects of this treatment approach.
Many people with HER2-positive stomach and esophageal cancers don't respond well enough to current treatments. This trial is testing whether adding this medication to the standard treatment plan might help more patients benefit and live longer.
You would receive the four-drug treatment combination on a regular schedule: chemotherapy and by IV every 2 weeks, by IV every 6 weeks, and as a daily pill that you take at home. The trial involves regular clinic visits for treatment infusions, blood tests, and imaging scans to monitor how you're responding. You'll be closely watched for side effects throughout your participation, and your heart function will be checked periodically because one of the medications can affect the heart.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
United States