Stem cell transplant with intensive chemotherapy for blood cancers with tumors outside the bone marrow

This trial is testing a stem cell transplant procedure combined with a high-dose chemotherapy regimen that includes thiotepa, busulfan, fludarabine, and cytarabine for patients with certain blood cancers that have spread outside the bone marrow. Researchers want to see if this intensive combination of chemotherapy drugs, followed by transplanted healthy blood-forming cells from a donor, can help control these cancers better and keep them from coming back.

Blood cancers that spread outside the bone marrow (called extramedullary involvement) are particularly difficult to treat and have high rates of relapse. This trial exists to test whether using a more intensive chemotherapy approach before the stem cell transplant can better eliminate these hard-to-reach cancer cells and improve long-term survival.