Plain-English translation of NCT06114628 on ClinicalTrials.gov ↗ · Source last updated ·
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether new combinations of tuberculosis drugs—including bedaquiline, delamanid, moxifloxacin, and others—can treat TB in as little as 8 to 16 weeks instead of the standard 24 weeks. The goal is to find regimens that work as well as or better than current treatment while being faster and easier to complete.
TB treatment currently takes 6 months, which is a long time for patients to stay on medication and can lead to people stopping treatment early. This trial is designed to find shorter treatment options that still cure TB effectively and safely.
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You will be randomly assigned to take one of several medication combinations for either 8, 16, or 24 weeks depending on which group you join. You'll attend regular clinic visits over 72 weeks total to take your medications (likely under supervision), have your TB status checked with sputum samples and imaging, and be monitored for any side effects. The study compares whether the newer, shorter regimens work as well as the standard 24-week treatment.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
Moldova
South Africa
Tanzania