A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(423 sites) United States
Clearview Cancer Institute, Huntsville, Alabama Banner MD Anderson Cancer Center, Gilbert, Arizona Banner University Medical Center Phoenix, Phoenix, Arizona The University of Arizona Cancer Center - North Campus, Tucson, Arizona Highlands Oncology Group, Springdale, Arkansas Cedars-Sinai Medical Center, Los Angeles, California Mercy Cancer Center, Merced, California Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California BASS Cancer Center, Walnut Creek, California USO - Rocky Mountain Cancer Centers, Lone Tree, Colorado Yale University School of Medicine, New Haven, Connecticut Sibley Memorial Hospital, Washington D.C., District of Columbia Millennium Oncology Research Clinic, Hollywood, Florida University of Florida - Jacksonville, Jacksonville, Florida Miami Cancer Institute at Baptist Health, Inc., Miami, Florida Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala, Ocala, Florida Comprehensive Hematology Oncology, St. Petersburg, Florida University Cancer & Blood Center, LLC, Athens, Georgia Emory University School of Medicine- Grady Campus, Atlanta, Georgia Winship Cancer Institute, Emory University, Atlanta, Georgia University of Illinois at Chicago, Chicago, Illinois University of Chicago Hospital, Chicago, Illinois Springfield Clinic Main Campus, Springfield, Illinois Parkview Research Center at Parkview Regional Medical Center, Fort Wayne, Indiana Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana Franciscan Health, Indianapolis, Indiana Community Cancer Center North, Indianapolis, Indiana The University of Kansas Cancer Center - Westwood, Westwood, Kansas CHI Saint Joseph Cancer Center - East, Lexington, Kentucky University of Kentucky Chandler Medical Center, Lexington, Kentucky Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana Johns Hopkins Bayview Medical Center, Baltimore, Maryland USO - Maryland Oncology Hematology, Columbia, Maryland Boston Medical Center, Boston, Massachusetts Lahey Hospital & Medical Center, Burlington, Massachusetts University of Michigan, Ann Arbor, Michigan Karmanos Cancer Institute, Detroit, Michigan The Cancer & Hematology Centers, Grand Rapids, Michigan Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis, Minnesota HealthPartners Cancer Research Center, Saint Paul, Minnesota North Mississippi Hematology and Oncology Associates, Tupelo, Mississippi Oncology Hematology Associates, Springfield, Missouri Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire The Valley Hospital, Inc., Paramus, New Jersey University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico Maimonides Cancer Center, Brooklyn, New York Northwell Health/ RJ Zuckerberg Cancer Center, Lake Success, New York Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York Laura and Isaac Perlmutter Cancer Center, New York, New York Manhattan Eye, Ear and Throat Hospital, New York, New York Memorial Sloan Kettering Cancer Center, New York, New York University of North Carolina Medical Center, Chapel Hill, North Carolina Duke Cancer Institute, Durham, North Carolina UNC REX Cancer Center, Raleigh, North Carolina USO - Oncology Hematology Care, Cincinnati, Ohio The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T, Columbus, Ohio USO - Oncology Associates of Oregon, Eugene, Oregon Asante Rogue Regional Medical Center, Medford, Oregon Providence Portland Medical Center, Portland, Oregon Providence St. Vincent Medical Center, Portland, Oregon Kaiser Permanente Interstate Medical Office Central, Portland, Oregon USO - Alliance Cancer Specialists, PC, Horsham, Pennsylvania Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office, Philadelphia, Pennsylvania UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania Lifespan Cancer Institute, Providence, Rhode Island Medical University of South Carolina, Charleston, South Carolina Prisma Health Cancer Institute, Greenville, South Carolina Lexington Medical Center, West Columbia, South Carolina Tennessee Oncology Chattanooga, Chattanooga, Tennessee University of Tennessee Medical Center, Knoxville, Tennessee Baptist Memorial Hospital-Memphis, Memphis, Tennessee Tennessee Oncology, Nashville, Tennessee USO - US Oncology Research Network, Nashville, Tennessee USO - Texas Oncology, Austin, Texas William Beaumont Army Medical Center, Fort Bliss, Texas Brooke Army Medical Center, Fort Sam Houston, Texas Houston Methodist Hospital, Houston, Texas University of Texas MD Anderson Cancer Center, Houston, Texas USO - Texas Oncology, Webster, Texas The University of Vermont Medical Center Inc., Burlington, Vermont University of Virginia Health System, Charlottesville, Virginia USO - Virginia Cancer Specialists, Fairfax, Virginia VCU Health Adult Outpatient Pavillion, Richmond, Virginia Swedish Cancer Institute - Edmonds, Edmonds, Washington Kadlec Clinic Hematology and Oncology, Kennewick, Washington Swedish Medical Center, Seattle, Washington VA Puget Sound Health Care System, Seattle, Washington USO - Northwest Cancer Specialists, Vancouver, Washington SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical, Madison, Wisconsin Australia
Royal Adelaide Hospital, Adelaide Icon Cancer Centre Wesley, Auchenflower Ballarat Health Services, Ballarat Central Sunshine Coast University Hospital, Birtinya Gosford Hospital, Gosford Mackay Base Hospital, Mackay St Vincent's Hospital, Melbourne Sir Charles Gairdner Hospital, Perth Goulburn Valley Health, Shepparton Gold Coast University Hospital, Southport The Townsville Hospital, Townsville Austria
Landeskrankenhaus Feldkirch, Feldkirch Ordensklinikum Linz GmbH Elisabethinen, Linz Klinik Floridsdorf, Vienna Belgium
CHIREC - site delta, Auderghem AZ Sint-Jan Brugge-Oostende AV, Bruges AZ Groeninge Campus Kennedylaan, Kortrijk AZ Sint-Maarten, Mechelen Clinique Saint Pierre, Ottignies Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir Brazil
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos Hospital Tacchini, Bento Gonçalves Hospital São Domingos, Bequimão Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul, Brasília Hospital Universitário Evangélico Mackenzie, Curitiba Centro de Pesquisa Clínica do Instituto do Câncer do Ceará, Fortaleza ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijuí Hospital Brasilia, Lago Sul Hospital de Cancer de Londrina, Londrina Liga Norte Riograndense Contra o Câncer, Natal Hospital São Lucas da PUCRS, Porto Alegre Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro
Canada
BC Cancer Abbotsford, Abbotsford British Columbia CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi BC Cancer Vancouver, Vancouver China
Cancer Hospital Chinese Academy of Medical Science, Beijing Beijing Cancer hospital, Beijing Jilin Province Tumor Hospital, Changchun Hunan Cancer Hospital, Changsha Hunan Cancer Hospital, Changsha The First People's Hospital of Changzhou, Changzhou The Third People's Hospital of Chengdu (CDTPH), Chengdu Sichuan Cancer hospital, Chengdu West China Hospital, Sichuan University, Chengdu Fujian Cancer Hospital, Fuzhou The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Hainan General Hospital, Haikou The First Affiliated Hospital, Zhejiang University, Hangzhou Czechia
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava Fakultni nemocnice Bulovka, Prague Denmark
Roskilde University Hospital, Roskilde France
Sainte Catherine Institut du Cancer Avignon Provence, Avignon Hospices Civils de Lyon - Hopital Louis Pradel, Bron CHU Lille - Institut Coeur Poumon, Lille Centre Leon Berard, Lyon Cedex08 Centre Antoine-Lacassagne, Nice CHU Bordeaux Haut-Leveque, Pessac Centre Hospitalier Universitaire de Poitiers, Poitiers Institut Jean Godinot, Reims Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes Institut de Cancérologie de l'Ouest, Saint-Herblain Nouvel Hôpital Civil (NHC), Strasbourg Germany
Evangelische Lungenklinik Berlin, Berlin Charité Campus Virchow-Klinikum, Berlin Helios Klinikum Emil von Behring Berlin-Zehlendorf, Berlin Klinikum Chemnitz, Chemnitz MV-Zentrum für Onkologie und Hämatologie, Cologne Onkologiezentrum Donauwörth, Donauwörth HELIOS Klinikum Erfurt, Erfurt Universitaetsklinikum Freiburg, Freiburg im Breisgau Asklepios Fachkliniken München-Gauting, Gauting Franziskus-Hospital Harderberg, Georgsmarienhütte LungenClinic Grosshansdorf, Großhansdorf Krankenhaus Martha-Maria Halle-Dölau, Halle Hämato-Onkologie Hamburg, Prof. Laack und Partner, Hamburg Greece
Agios Savvas Regional Cancer Hospital, Athens Errikos Dunant Hospital Center, Athens Sotiria Thoracic Diseases Hospital of Athens, Athens Attikon General University Hospital, Chaïdári University General Hospital of Heraklion, Heraklion University Hospital of Patras, Pátrai "Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki European Interbalkan Medical Center, Thessaloniki G. Papanikolaou General Hospital, Thessaloniki Hungary
Országos Korányi Pulmonológiai Intézet, Budapest Országos Onkológiai Intézet, Budapest Budapesti Uzsoki Utcai Kórház, Budapest Farkasgyepui Tudogyogyintezet, Farkasgyepű Bacs-Kiskun Megyei Korhaz, Kecskemét India
Hemato Oncology Clinic, Ahmedabad KLES Dr. Prabhakar Kore Hospital & M.R.C, Belagavi All India Institute of Medical Sciences, Bhubaneswar Ashwin Hospital, Coimbatore Nizam's Institute of Medical Sciences, Hyderabad Krishna Institute of Medical Sciences - Karad, Karad Kolhapur Cancer Centre Private Limited, Kolhāpur HCG Manavata Cancer Centre, Nashik Advanced Centre for Treatment Research and Education in Cancer, Navi Mumbai Jawaharlal Institute Of Postgraduate Medical Education And Research, Puducherry Grant Medical Foundation - Ruby Hall Clinic, Pune Sahyadri Super Speciality Hospital, Pune
Italy
Instituto Tumori Giovanni Paolo II, Bari IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna Policlinico "G. Rodolico", Catania Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples Istituto Oncologico Veneto IRCCS, Padova Fondazione Policlinico Universitario Agostino Gemelli, Roma Istituto Nazionale Tumori Regina Elena, Rome Ospedale di Circolo e Fondazione Macchi Varese, Varese Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona Japan
National Hospital Organization Asahikawa Medical Center, Asahikawa Juntendo University Hospital, Bunkyō City Tokyo Metropolitan Komagome Hospital, Bunkyō City National Hospital Organization Kyushu Cancer Center, Fukuoka Kyushu University Hospital, Fukuoka Saitama Medical University International Medical Center, Hidaka Himeji Medical Center, Himeji Kansai Medical University Hospital, Hirakata Kanazawa University Hospital, Kanazawa Ibaraki Prefectural Central Hospital, Kasama National Cancer Center Hospital East, Kashiwa Kobe City Medical Center General Hospital, Kobe Japanese Foundation for Cancer Research, Kōtō City
Mexico
CIO - Centro de Inmuno-Oncología de Occidente, Guadalajara PanAmerican Clinical Research - Guadalajara, Guadalajara Actualidad Basada en la Investigación del Cáncer, Guadalajara Renati Innovation, Guadalajara Health Pharma Querétaro, Juriquilla Preparaciones Oncológicas S.C., León Health Pharma Professional Research S.A. de C.V:, Mexico City Centro Onco-Hematológico Roma (COHR), Mexico City Higiea Oncologia, Mexico City Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey Avix Investigación Clinica, S.C., Monterrey Centro de Investigacion Clinica de Oaxaca, Oaxaca City Clinica Integral Internacional de Oncología, Puebla City
Netherlands
Jeroen Bosch Hospital, 's-Hertogenbosch Medisch Spectrum Twente, Enschede Ziekenhuis St. Jansdal, Harderwijk Tergooiziekenhuizen, locatie Hilversum, Hilversum Frisius Medisch Centrum, Leeuwarden Leids Universitair Medisch Centrum, Leiden Erasmus Medisch Centrum, Rotterdam St. Antonius Ziekenhuis, locatie Utrecht, Utrecht Norway
Haukeland Universitetssjukehus, Bergen Drammen Sykehus, Vestre Viken HF, Drammen Sykehuset Innlandet HF Gjøvik, Gjøvik Akershus Universitetssykehus, Lørenskog Oslo universitetssykehus, Radiumhospitalet, Oslo Stavanger Universitetssykehus, Stavanger St. Olavs Hospital, Trondheim Poland
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Kielce MICS Centrum Medyczne Torun, Torun Portugal
Centro Hospitalar E Universitário De Coimbra, Coimbra Champalimaud Foundation, Lisbon Hospital da Luz Lisboa, Lisbon Hospital Pulido Valente, Lisbon Centro Hospitalar do Porto - Hospital de Santo António, Porto Hospital CUF Porto, Porto Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto Romania
SC Memorial Healthcare International SRL, Bucharest Gral Medical Diagnostic Center, Bucharest Institutul Oncologic, Cluj-Napoca Centrul de Oncologie "Sfântul Nectarie", Craiova Ovidius Clinical Hospital OCH, Ovidiu S C Oncocenter Oncologie Clinica S R L, Timișoara Cabinet Medical Oncomed, Timișoara South Korea
Chungbuk National University Hospital, Cheongju-si Keimyung University Dongsan Hospital, Daegu Kyungpook National University Chilgok Hospital, Deagu Gangnam Severance Hospital, Yonsei University Health System, Gangnam-gu National Cancer Center, Goyang-si Chonnam National University Hwasun Hospital, Hwasun Korea University Anam Hospital, Seoul Severance Hospital, Yonsei University Health System, Seoul Hanyang University Seoul Hospital, Seoul Asan Medical Center, Seoul Samsung Medical Center, Seoul The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul Korea University Guro Hospital, Seoul Spain
CHUAC-Hospital Teresa Herrera, A Coruña Hospital Infanta Cristina, Badajoz OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo Parc de Salut Mar - Hospital del Mar, Barcelona Hospital Universitari Dexeus, Barcelona Hospital Universitari Vall d'Hebron, Barcelona Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet Hospital Jerez de la Frontera, Jerez de la Frontera Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria Complejo Asistencial Universitario de León - Hospital de León, León Hospital Universitario Ramón y Cajal, Madrid Hospital Universitario 12 de Octubre, Madrid H.R.U Málaga - Hospital General, Málaga
Sweden
Mälarsjukhuset, Eskilstuna Västmanlands Sjukhus Västerås, Västerås Switzerland
CHUV (centre hospitalier universitaire vaudois), Lausanne Kantonsspital Winterthur, Winterthur UniversitätsSpital Zürich, Zurich Taiwan
Changhua Christian Hospital, Changhua County Buddhist Dalin Tzu Chi General Hospital, Chiayi City National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region, Douliu Hualien Tzu Chi Medical Center, Hualien City Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist New Taipei Municipal TuCheng Hospital, New Taipei City Chung Shan Medical University Hospital, Taichung Taichung Veterans General Hospital, Taichung National Cheng Kung University Hospital, Tainan Chi Mei Medical Center, Tainan Chi Mei Hospital - Liouying Branch, Tainan National Taiwan University Hospital, Taipei
Turkey (Türkiye)
Adana Medical Park Seyhan Hastanesi, Adana Adana City Hospital, Adana Ankara Etlik City Hospital, Ankara Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital, Ankara Ankara Bilkent Şehir Hastanesi, Ankara Akdeniz Universitesi Hastanesi, Antalya Memorial Antalya Hospital, Antalya Antalya Egitim ve Arastırma Hastanesi, Antalya Uludag Universitesi, Bursa Dicle Üniversitesi, Diyarbakır Bezmialem Vakf Üniversitesi, Istanbul İ.A.Ü VM Medical Park Florya Hastanesi, Istanbul TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul United Kingdom
Aberdeen Royal Infirmary, Aberdeen Ninewells Hospital and Medical School, Dundee Huddersfield Royal Infirmary, Huddersfield St James's University Hospital, Leeds The Christie NHS Foundation Trust, Manchester Mount Vernon Hospital, Northwood Weston Park Hospital, Sheffield New Cross Hospital, Wolverhampton
Key details Sponsor
Eli Lilly and Company
Enrollment target
~1,264 participants
Primary completion
November 2027
Age range
18 Years and older
Last updated March 2026
Interested in joining? Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro
Instituto D'Or Pesquisa e Ensino, Rio de Janeiro Clinica Amo - Rio Vermelho, Salvador Faculdade de Medicina do ABC, Santo André Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto COE Ensino e Pesquisa, São José dos Campos Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo Hospital Sírio Libanês, São Paulo Hospital Santa Catarina - Paulista, São Paulo Hospital Paulistano, São Paulo Centro Paulista de Oncologia Clínica, São Paulo Núcleo de Pesquisa Clínica da Rede São Camilo, São Paulo Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T, São Paulo Instituto D'Or de Pesquisa e Ensino (IDOR), São Paulo Sir Run Run Shaw Hospital, Hangzhou
Zhejiang Cancer Hospital, Hangzhou Harbin Medical University Cancer Hospital, Harbin Jinan Central Hospital, Jinan Shandong Cancer Hospital, Jinan Taizhou Hospital of Zhejiang Province, Linhai LinYi Cancer Hospital, Linyi Liuzhou People's Hospital, Liuchow The First Affiliated Hospital of Nanchang University, Nanchang Nanjing First Hospital, Nanjing Shanghai Chest Hospital, Shanghai Tianjin Medical University Cancer Institute & Hospital, Tianjin Xinjiang Medical University Cancer Hospital - Urumqi, Ürümqi Tongji Hospital Tongji Medical,Science & Technology, Wuhan Wuhan Union Hospital, Wuhan Renmin Hospital of Wuhan University, Wuhan Wannan Medical College Yijishan Hospital, Wuhu The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Xiangyang Central Hospital, Xiangyang Yichang Central People's Hospital, Yichang Affiliated Hospital of Guangdong Medical University, Zhanjiang ZhuZhou Central Hospital, Zhuzhou Centre Hospitalier intercommunal de Toulon La Seyne sur Mer, Toulon
CHU de Toulouse - Hopital Larrey, Toulouse Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandœuvre-lès-Nancy Hôpital Robert Schuman, Vantoux Gustave Roussy, Villejuif Asklepios Klinik Harburg, Hamburg
Thoraxklinik-Heidelberg gGmbH, Heidelberg Universitätsklinikum Münster - Albert Schweitzer Campus, Münster Klinikum Nürnberg Nord, Nuremberg Universitaetsklinikum Tuebingen, Tübingen Lifepoint Multispeciality Hospital, Pune
Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram Pacific Medical College & Hospital, Udaipur Tata Memorial Centre - Homi Bhabha Cancer Hospital, Varanasi Mahatma Gandhi Cancer Hospital and Research Institute, Visakhapatnam University Hospital,Kyoto Prefectural University of Medicine, Kyoto
National Hospital Organization Shikoku Cancer Center, Matsuyama Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun Nagasaki University Hospital, Nagasaki Aichi Cancer Center Hospital, Nagoya Miyagi Cancer Center, Natori Niigata Cancer Center Hospital, Niigata Okayama University Hospital, Okayama Kindai University Hospital- Osakasayama Campus, Sakai National Hospital Organization Kinki-chuo Chest Medical Center, Sakai Hokkaido University Hospital, Sapporo National Hospital Organization Yamaguchi Ube Medical Center, Ube Tochigi Cancer Center, Utsunomiya Wakayama Medical University Hospital, Wakayama Kanagawa Cardiovascular and Respiratory Center, Yokohama Kanagawa cancer center, Yokohama Tottori University Hospital, Yonago Oncare - Unidad Valle, San Pedro Garza García
Arké SMO S.A de C.V, Veracruz The Catholic University Of Korea St. Vincent's Hospital, Suwon
Pusan National University Yangsan Hospital, Yangsan Hospital Universitari Son Espases, Palma
Complejo Hospitalario de Navarra, Pamplona Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón CHUS - Hospital Clinico Universitario, Santiago de Compostela Hospital Universitario Virgen Del Rocio, Seville Hospital Clinico de Valencia, Valencia Hospital Clínico Universitario Lozano Blesa, Zaragoza National Taiwan University Cancer Center (NTUCC), Taipei
Taipei Veterans General Hospital, Taipei Chang Gung Medical Foundation-Linkou Branch, Taoyuan District National Taiwan University Hospital - Hsinchu branch, Zhubei Ege Universitesi Hastanesi, Izmir
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi, Izmir Kocaeli Üniversitesi, Kocaeli Ondokuz Mayıs Universitesi, Samsun