Plain-English translation of NCT06125925 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether a procedure called catheter ablation works better than antiarrhythmic drugs (medications that control heart rhythm) for patients who have both atrial fibrillation—an irregular heartbeat—and heart failure with preserved ejection fraction, a condition where your heart pumps blood well but has trouble relaxing between beats. The researchers want to know if this treatment can help you live longer and stay out of the hospital.
We know this treatment works well for patients whose heart pumps weakly, but we don't yet have clear evidence that it's better than medication alone for patients whose heart pumps normally but doesn't relax properly. This trial will help doctors decide the best approach for your specific type of heart condition.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will first enter a 5-week run-in period where your heart medications and blood thinner will be optimized. Then you will be randomly assigned to one of two groups: either the catheter ablation procedure (which uses heat to correct the irregular heartbeat) or long-term medication therapy. You will have follow-up visits over 2–3 years with blood tests, heart imaging, and check-ups to track how you're doing.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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