Recruiting

Building a genetic database for ovarian cancer treatment planning

Plain-English translation of NCT06127446 on ClinicalTrials.gov ↗ ·

What is this trial?

Researchers are creating a genetic database of ovarian cancer by collecting tumor tissue and blood samples from 300 patients with high-grade serous or clear cell ovarian cancer. They will study the genetic makeup of these samples to understand why some cancers resist treatment and to discover new ways to treat ovarian cancer more effectively.

Ovarian cancer often becomes resistant to treatment, and doctors don't fully understand why this happens or how to prevent it. By studying the genes in tumor tissue from many patients, researchers hope to find patterns that explain drug resistance and identify new, personalized treatment strategies.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have been diagnosed with stage I–IV high-grade serous or clear cell ovarian cancer (or cancer of the fallopian tube or peritoneum)
you have had surgery to remove your primary tumor
you are willing to donate tumor tissue, normal tissue, and a blood sample for genetic testing
you are willing to attend regular follow-up appointments and have a life expectancy of at least 3 months

You likely don't qualify if…

you have been diagnosed with both ovarian and endometrial cancer at the same time
your tumor tissue sample is more than 5 years old
your tumor tissue is too damaged or degraded for genetic testing
you have been treated for another cancer in the past 3 years (except skin cancer)
you are unable or unwilling to follow the study plan and attend appointments

What participation looks like

If you join, you will donate surgical tissue from your tumor (and from recurrent tumors if applicable) and provide a blood sample within four weeks of enrollment. Researchers will perform detailed genetic testing on these samples to map your cancer's genetic characteristics. You will also share information about your medical history, previous treatments, and how you responded to them, and participate in regular follow-up visits so the research team can track your progress.

Building a genetic database for ovarian cancer treatment planning

What is this trial?

Do you qualify?

What participation looks like

Trial locations(8 sites)