Plain-English translation of NCT06128993 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
When you have a heart attack, doctors need to quickly open the blocked artery causing it. This trial is testing whether adding a simple cooling treatment—flushing room-temperature saline through the catheter used in the procedure—can protect your heart muscle from additional damage. The cooling happens during your standard emergency treatment, so it doesn't add extra time or major steps.
Even after doctors open a blocked artery, the sudden rush of blood back to starved heart muscle can cause extra damage. This trial is exploring whether gently cooling that returning blood can reduce this 'reperfusion injury' and help your heart recover better.
You likely qualify if…
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You would be randomly assigned to receive either the cooling treatment or standard care during your emergency catheterization procedure at Harefield Hospital. A special catheter wire would measure temperature and blood pressure throughout your procedure. After the procedure, you would have blood tests and heart imaging (MRI scans) to check how much of your heart was protected. The study involves 60 patients total, and you would be one of 30 in either the treatment or standard care group.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
United Kingdom
Sponsor
Royal Brompton & Harefield NHS Foundation Trust
Enrollment target
~60 participants
Started
November 2023
Primary completion
January 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Miles C Dalby, MD
Royal Brompton & Harefield NHS Foundation Trust
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.