Plain-English translation of NCT06129214 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study compares two surgical approaches to total knee replacement in patients with severe knee arthritis or bone death in the knee. One group will have a procedure where surgeons remove a small amount of tissue (synovium) from the quadriceps tendon area during surgery, while the other group will have standard knee replacement without this tissue removal. Researchers want to see if removing this tissue reduces clicking and crackling sensations after surgery.
Some patients experience clicking or crackling sensations in their knee after replacement surgery, which can be uncomfortable and bothersome. This trial is investigating whether removing a specific area of tissue during the initial surgery can prevent or reduce these sounds and improve overall quality of life after the procedure.
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If you enroll, you will have knee replacement surgery performed by the study team, and you'll be randomly assigned to either receive tissue removal during surgery or standard surgery without tissue removal. Before surgery, you'll undergo imaging tests and physical examinations to establish a baseline. After surgery, you'll have follow-up appointments at 3 months, 6 months, and 1 year, where doctors will assess any clicking or crackling sensations, measure your knee movement, and ask you to complete questionnaires about your pain and quality of life.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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