Plain-English translation of NCT06132477 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
Researchers at the University of Missouri are studying what happens when people continue or stop taking semaglutide, tirzepitide, or similar weight loss medications after undergoing bariatric (stomach) surgery. The study will randomly assign participants to either keep taking their medication at the same dose after surgery, or to stop taking it. By comparing these two groups, researchers hope to understand which approach leads to better weight loss and overall health improvements.
Right now, doctors don't have clear guidelines about whether patients should continue their weight loss medication after stomach surgery, or whether the surgery alone is enough. This study aims to answer that important question so doctors can give better advice to their patients.
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If you join this study, you will be randomly assigned to either continue taking your current weight loss medication after surgery or to stop taking it. Before your surgery and at defined time points afterward, you will have blood drawn and your health data collected. The study team will follow you after your surgery to monitor your weight loss, blood sugar levels, and overall health. The exact duration of the study will depend on the research aims, but you'll need to commit to attending your scheduled follow-up appointments.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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