Recruiting

Exercise and diet to improve life quality in advanced stomach and esophagus cancer

Plain-English translation of NCT06138223 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether a combined exercise and nutrition program can improve quality of life for people with advanced stomach or esophagus cancer that cannot be cured. You would either receive the new program (which includes structured exercise and dietary guidance plus an activity tracker) or standard care with written guidelines and an activity tracker. The study wants to learn if a more structured, personalized approach to movement and eating helps people feel better, stay stronger, and improve their overall wellbeing during cancer treatment.

People with advanced stomach and esophagus cancer often lose muscle, feel weak, and experience a decline in quality of life during treatment. Researchers believe that a focused program combining exercise and nutrition guidance could help preserve strength, improve energy and mood, and give patients more control over their health during this difficult time.

Do you qualify?

You likely qualify if…

you have been diagnosed with incurable adenocarcinoma (cancer) of the esophagus or stomach that has returned after previous treatment or was advanced at diagnosis
you are willing and able to participate in an exercise and nutrition program and wear an activity tracker
you are willing to complete quality-of-life questionnaires throughout the study
you have a life expectancy of more than 12 weeks as determined by your doctor
you are 18 years of age or older

You likely don't qualify if…

you have unstable bone metastases (cancer spread to bones) that make your bones fragile
you have untreated brain metastases (cancer in the brain) causing symptoms
you have uncontrolled severe pain or serious active infection
you have severe heart, lung, or neurological problems that would make exercise unsafe, or you depend on oxygen at rest
you are already exercising more than 210 minutes per week at a moderate-to-vigorous level

What participation looks like

If you join this trial, you will be randomly assigned to either the exercise-and-nutrition program group or the standard care group. The intervention group will receive a structured program with personalized exercise guidance (designed to build toward 150 minutes per week of activity) and nutritional counseling, along with an activity tracker to monitor movement. The standard care group will receive usual medical care, written guidelines about physical activity and diet, and an activity tracker without specific instructions. Both groups will complete questionnaires about quality of life at various timepoints during the study. The study involves regular visits to the research center to check on your progress and answer questions.

AI-generated summary from trial data · Aug 5, 2026 · Not medical advice

Exercise and diet to improve life quality in advanced stomach and esophagus cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(22 sites)