Plain-English translation of NCT06138821 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing endoscopic sleeve gastroplasty—a minimally invasive procedure performed through the mouth that reshapes the stomach to help you feel fuller faster—combined with a 12-month lifestyle modification program. The study will compare people who receive this procedure plus lifestyle coaching against people who only receive lifestyle coaching, to see which approach works better for weight loss and improving fatty liver disease.
Most people who try diet and exercise alone don't lose enough weight to reverse fatty liver disease, and current weight loss medications have mixed results and can be expensive. This trial is testing whether a minimally invasive procedure might offer a more effective and lasting solution for people with obesity and liver damage.
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If you are in the procedure group, you will receive the endoscopic sleeve gastroplasty (a 30-60 minute procedure done while you are sedated) and then participate in a structured 12-month lifestyle program with diet counseling and follow-up visits. If you are in the comparison group, you will participate in the same 12-month lifestyle program without the procedure. Both groups will have regular clinic visits, blood tests, and imaging to track weight loss and liver health over the year.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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