Recruiting

Comparing two sedation medications during emergency stroke treatment

Plain-English translation of NCT06139692 on ClinicalTrials.gov ↗ · Source last updated November 2025 · Translation generated July 2026 · How we translate trials

Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

When you have an acute ischemic stroke caused by a blood clot in a major brain artery, doctors perform an emergency procedure called endovascular thrombectomy to remove the clot. During this procedure, you need to be sedated (kept calm and comfortable) but still able to follow commands. This trial is comparing two sedation medications— and —to see which one helps patients recover better and have fewer complications after this emergency treatment.

Both medications are used in clinical practice, but doctors aren't sure which one is safer or more effective for stroke patients during this procedure. This trial aims to provide clear evidence to help doctors choose the best sedation approach for emergency stroke care.

Do you qualify?

You likely qualify if…

you are 18 years of age or older
you are having symptoms of an acute ischemic stroke caused by a large blood clot in the front part of your brain
you can be enrolled in the study within 24 hours of when your stroke symptoms started or when you were last known to be well
you were functioning well before your stroke (able to care for yourself with minimal help)
you have a moderate to severe stroke (a specific score of 6 or higher on a stroke severity scale)

You likely don't qualify if…

you are pregnant or breastfeeding
you have a known allergy to either of the study medications or to contrast dye used during the procedure
you have uncontrolled high or low blood pressure or a serious heart rhythm condition
you have a bleeding disorder or are taking blood-thinning medications that cannot be reversed
you have severe kidney disease or are on dialysis

What participation looks like

If you qualify and agree to participate, you will be randomly assigned to receive one of the two sedation medications during your emergency stroke procedure. The doctors will monitor you carefully during and after the procedure to make sure the medication is working safely. You will then be followed up for 90 days after your procedure, with assessments at regular intervals to see how well you are recovering and whether the treatment helped improve your stroke outcome.

AI-generated summary from trial data · Jul 22, 2026 · Not medical advice

Trial locations(2 sites)

China

Jinling Hospital, Medical School of Nanjing University, Nanjing, None Selected

The General Hospital of Western Theater Command PLA, Chengdu