Plain-English translation of NCT06144203 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our PTSD research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is testing whether aerobic exercise—done right after a therapeutic session that helps reduce fear responses—can improve how well people with PTSD recover from trauma-related fears. The study will compare three different exercise intensities (light, moderate, and high) to see which works best. Researchers will measure changes in thinking, body responses, and brain activity to understand how exercise might strengthen fear recovery.
Many people with PTSD struggle with lingering fear responses even after therapy. This study explores whether adding exercise to fear-extinction therapy (a well-established treatment) could boost the brain's ability to consolidate and remember the fear-reduction learning, potentially making recovery more complete and lasting.
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You will visit the study site on four days over about one week. On day one, you'll complete a clinical intake and undergo a fear-conditioning session (where you learn to associate a neutral cue with a mild, safe stimulus). On day two, you'll do a fear-extinction session (learning that the cue is now safe) followed immediately by 30 minutes of aerobic exercise at one of three intensity levels, assigned randomly. On day three, you'll return to test whether the fear-extinction learning stuck. Throughout, researchers will use brain imaging, heart rate monitoring, and questionnaires to track your progress.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States